The impact of Nintendo’s "for men" advertising campaign on a potential female market

In order to emphasize the maturation of their hand-held console and increase its appeal to an adult market, Nintendo's UK advertising campaign for the Game Boy Advance SP drew explicitly upon 'lad' culture and a tongue-in-cheek appropriation of cologne advertising. In this campaign, the lead and most prominent promotional advert for the device used an image of the Game Boy with the tagline "For Men". This paper outlines why Nintendo's decision to present the Game Boy as a male accessory prompted exploration into its potential impact on the female market. Much of the emerging research field examining female participation in game cultures had at that point tended to focus its attention on exploring the experiences of different female groups with a variety of software titles and its associated communities. In contrast, this paper addresses participants' perceptions of the gaming industry and its relevance to them as a (potential) consumer by taking a hardware device as its focus. This was achieved by conducting a series of focus groups, with a range of both experienced and inexperienced female game players, during which participants were asked to engage with the hand-held device and experience both its single and networked game-play capabilities with the game Legend of Zelda. The findings address participants' awareness and views on the extent to which gaming is coded male and its ramifications for their participation in game cultures

Wake Me Up When There's a Crisis: Progress on State Pandemic Influenza Ethics Preparedness

We assessed the progress since 2005 of state plans for pandemic influenza and found that 7 states had recommended steps to further clarify ethical processes or decisions; 6 states had made some progress but almost exclusively in hospital preparedness. Having a high-level public health leader, such as a health department director, committed to ethics was the key determinant of progress. Some state health departments may be destined to gain an appreciation for ethics through ethical mishaps

Experimental muscle hyperalgesia modulates sensorimotor cortical excitability, which is partially altered by unaccustomed exercise

Impaired corticomotor function is reported in patients with lateral epicondylalgia, but the causal link to pain or musculotendinous overloading is unclear. In this study, sensorimotor cortical changes were investigated using a model of persistent pain combined with an overloading condition. In 24 healthy subjects, the effect of nerve growth factor (NGF)-induced pain, combined with delayed-onset muscle soreness (DOMS), was examined on pain perception, pressure pain sensitivity, maximal force, and sensorimotor cortical excitability. Two groups (NGF alone and NGF + DOMS) received injections of NGF into the extensor carpi radialis brevis (ECRB) muscle at day 0, day 2, and day 4. At day 4, the NGF + DOMS group undertook wrist eccentric exercise to induce DOMS in the ECRB muscle. Muscle soreness scores, pressure pain thresholds over the ECRB muscle, maximal grip force, transcranial magnetic stimulation mapping of the cortical ECRB muscle representation, and somatosensory-evoked potentials from radial nerve stimulation were recorded at day 0, day 4, and day 6. Compared with day 0, day 4 showed in both groups: (1) increased muscle soreness (P < 0.01); (2) reduced pressure pain thresholds (P < 0.01); (3) increased motor map volume (P < 0.01); and (4) decreased frontal N30 somatosensory-evoked potential. At day 6, compared with day 4, only the DOMS + NGF group showed: (1) increased muscle soreness score (P < 0.01); (2) decreased grip force (P < 0.01); and (3) decreased motor map volume (P < 0.05). The NGF group did not show any difference on the remaining outcomes from day 4 to day 6. These data suggest that sustained muscle pain modulates sensorimotor cortical excitability and that exercise-induced DOMS alters pain-related corticomotor adaptation

Left dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation reduces the development of long-term muscle pain

The left dorsolateral prefrontal cortex (DLPFC) is involved in the experience and modulation of pain, and may be an important node linking pain and cognition. Repetitive transcranial magnetic stimulation (rTMS) to the left DLPFC can reduce chronic and experimental pain. However, whether left DLPFC rTMS can influence the development of chronic pain is unknown. Using repeated intramuscular injection of nerve growth factor to induce the development of sustained muscle pain (lasting weeks), 30 healthy individuals were randomized to receive 5 consecutive daily treatments of active or sham left DLPFC rTMS, starting before the first nerve growth factor injection on day 0. Muscle soreness and pain severity were collected daily for 14 days and disability on every alternate day. Before the first and 1 day after the last rTMS session, anxiety, depression, affect, pain catastrophizing, and cognitive performance on the attention network test were assessed. Left DLPFC rTMS treatment compared with sham was associated with reduced muscle soreness, pain intensity, and painful area (P < 0.05), and a similar trend was observed for disability. These effects were most evident during the days rTMS was applied lasting up to 3 days after intervention. Depression, anxiety, pain catastrophizing, and affect were unchanged. There was a trend toward improved cognitive function with rTMS compared with sham (P = 0.057). These data indicate that repeated left DLPFC rTMS reduces the pain severity in a model of prolonged muscle pain. The findings may have implications for the development of sustained pain in clinical populations

High frequency repetitive transcranial magnetic stimulation to the left dorsolateral prefrontal cortex modulates sensorimotor cortex function in the transition to sustained muscle pain

Based on reciprocal connections between the dorsolateral prefrontal cortex (DLPFC) and basal-ganglia regions associated with sensorimotor cortical excitability, it was hypothesized that repetitive transcranial magnetic stimulation (rTMS) of the left DLPFC would modulate sensorimotor cortical excitability induced by muscle pain. Muscle pain was provoked by injections of nerve growth factor (end of Day-0 and Day-2) into the right extensor carpi radialis brevis (ECRB) muscle in two groups of 15 healthy participants receiving 5 daily sessions (Day-0 to Day-4) of active or sham rTMS. Muscle pain scores and pressure pain thresholds (PPTs) were collected (Day-0, Day-3, Day-5). Assessment of motor cortical excitability using TMS (mapping cortical ECRB muscle representation) and somatosensory evoked potentials (SEPs) from electrical stimulation of the right radial nerve were recorded at Day-0 and Day-5. At Day-0 versus Day-5, the sham compared to active group showed: Higher muscle pain scores and reduced PPTs (P < 0.04); decreased frontal N30 SEP (P < 0.01); increased TMS map volume (P < 0.03). These results indicate that muscle pain exerts modulatory effects on the sensorimotor cortical excitability and left DLPFC rTMS has analgesic effects and modulates pain-induced sensorimotor cortical adaptations. These findings suggest an important role of prefrontal to basal-ganglia function in sensorimotor cortical excitability and pain processing

Getting It Right: The MISE Approach to Professional Development

With an initial 10-year commitment from Merck & Co., Inc. the Merck Institute for Science Education (MISE) was founded in 1993 to demonstrate that virtually all students could reach high levels of scientific literacy. Shortly thereafter, MISE formed partnerships with four public school districts -- Linden, Rahway, and Readington Township in New Jersey, and North Penn in Pennsylvania -- where Merck has major facilities and a history of providing employee volunteers and supporting local science education initiatives. These district partnerships quickly merged into one multi-district Partnership. MISE\u27s approach to improving science teaching has been systemic, addressing both policy and practice in the partner districts. MISE has helped its partners plan strategically, select highquality instructional resources, support teacher learning, and carry out instructional and curricular reforms. Working together, MISE and its partner districts have developed and implemented a shared vision of good science instruction based on national and state standards. This vision has been the basis for the design and delivery of professional development for teachers and administrators. Sustained by the Partnership since 1994, this professional development program has helped the partner districts make significant reforms in the teaching of science and mathematics. In 1993, MISE contracted with the Consortium for Policy Research in Education (CPRE) at the University of Pennsylvania to evaluate the effectiveness of its work with the four districts. CPRE has documented the activity and progress of the Partnership for a decade and has issued a series of reports on its impact. In this report, we assess the Partnership’s approach to professional development. Specifically, we address the following questions: 1. How has the Partnership’s professional development measured up against the emerging standards for professional development? 2. Has participation in Partnership professional development resulted in increased teacher content knowledge? 3. Has participation in Partnership professional development led to changes in instructional practice? 4. Has participation in Partnership professional development resulted in improved student achievement? 5. Has MISE’s strategy strengthened district capacity to support the improvement of teaching? 6. What lessons can be learned from the experience of MISE and the Partnership with professional development

PhagePhisher: a Pipeline for the Discovery of Covert Viral Sequences in Complex Genomic Datasets

Obtaining meaningful viral information from large sequencing datasets presents unique challenges distinct from prokaryotic and eukaryotic sequencing efforts. The difficulties surrounding this issue can be ascribed in part to the genomic plasticity of viruses themselves as well as the scarcity of existing information in genomic databases. The open-source software PhagePhisher (http://www.putonti-lab.com/phagephisher) has been designed as a simple pipeline to extract relevant information from complex and mixed datasets, and will improve the examination of bacteriophages, viruses, and virally related sequences, in a range of environments. Key aspects of the software include speed and ease of use; PhagePhisher can be used with limited operator knowledge of bioinformatics on a standard workstation. As a proof-of-concept, PhagePhisher was successfully implemented with bacteria–virus mixed samples of varying complexity. Furthermore, viral signals within microbial metagenomic datasets were easily and quickly identified by PhagePhisher, including those from prophages as well as lysogenic phages, an important and often neglected aspect of examining phage populations in the environment. PhagePhisher resolves viral-related sequences which may be obscured by or imbedded in bacterial genomes

Flexible surface electrodes targeting biopotential signals from forearm muscles for control of prosthetic hands: Part 1 - Characterisation of semg electrodes

This study is Part 1 of two studies which investigate the use of various flexible surface sensors as an alternative to the gold standard Ag/AgCl surface electromyography (sEMG) electrodes in identifying movement intention from a user during common hand gestures. Three conductive textiles, two commercial conductive elastomers and one E-skin elastomer produced on site were tested as biopotential electrodes to establish the efficacy of each in gathering movement intention from the human brain at the level of the muscle. Testing was performed in vivo on two participants across three hand gestures, with results demonstrating that sEMG electrodes made from a commercially sourced conductive fabric can outperform the traditional Ag/AgCl sEMG electrodes, obtaining substantially larger peak and RMS measurements. Given the disadvantages of Ag/AgCl electrodes over long usage periods, namely their tendency to dry out and significant skin preparation, resulting in variable impedances and skin irritation respectively, the incorporation of flexible surface EMG electrodes in hand prosthetic control systems would increase functionality of the prosthetic devices, consequently increasing the quality of life of prosthetic hand users

Comparison of climate signals obtained from encrusting and free-living rhodolith coralline algae

Highlights • Comparison of encrusting and rhodolith coralline algae for paleoclimate reconstruction • Both coralline algal forms can yield SST information, but encrusting forms generally yield higher correlations to SST. • Encrusting morphologies yielded longer records due to frequent growth irregularities in rhodoliths. Abstract Coralline algae have been used for sclerochronological studies throughout the last decade. These studies have focused on two different growth morphologies of the photosynthetic coralline algae: massive crusts forming small buildups on hard substrate, and free-living branching algal nodules, known as rhodoliths. The latter are generally found on soft-substrate, where they are frequently overturned by water movement and bottom feeding organisms, leaving one side of the rhodolith partially buried in the sediment at any given time. Here we test whether either of these growth morphologies is more suitable for proxy reconstructions by comparing Mg/Ca ratios – a temperature proxy – in multiple replicates of rhodoliths of Lithothamnion glaciale and in rhodoliths as well as encrusting specimens of Clathromorphum compactum. With both species being widespread throughout the Temperate and Arctic regions, we have chosen two North Atlantic localities at Nuuk Fjord, Greenland (Subarctic), and off the southeastern coast of Newfoundland, Canada (Temperate), for this study. Two to three Mg/Ca ratio transects spanning 18 years of growth were analysed on multiple specimens with encrusting morphologies and along different sides of rhodoliths using laser ablation inductively coupled mass spectrometry and compared to remotely sensed sea surface temperature (SST) data. The length of the common time span used for comparison was limited by growth interruptions in rhodoliths. Furthermore, our comparison is based on the assumption that rhodolith growth increments are annual – an assumption that has recently been challenged by mesocosm studies. Monthly Mg/Ca values from multiple transects within each individual were compared and in samples from Nuuk fjord significant correlations were found in 4 of 4 encrusting C. compactum, 4 of 4 C. compactum rhodoliths, and 2 of 3 L. glaciale rhodoliths. In Newfoundland significant correlations were found in 6 of 6 encrusting C. compactum comparisons (average: r = 0.61, p < 0.001), and in 6 of 6 L. glaciale rhodolith comparisons (average: r = 0.43, p < 0.001) for monthly resolved time series. The monthly Mg/Ca ratios (n = 216) from each morphology were compared with instrumental Reynolds SST yielding the following correlations: encrusting C. compactum (r = 0.64, p < 0.001), C. compactum rhodolith (r = 0.62, p < 0.001) and L. glaciale (r = 0.58, p < 0.001). In Newfoundland both morphologies indicate a similar strength in recording SST: encrusting C. compactum (r = 0.85, p < 0.001) and rhodolith-forming L. glaciale (r = 0.84, p < 0.001). In summary, Mg/Ca ratios derived from both coralline algal growth forms can yield SST information, however, massive encrusting forms generally yield higher correlations to SST than transects measured on individual rhodoliths, which only allowed for the generation of short uninterrupted time series due to frequent growth irregularities